notebook.community

Edit and run

Introduction

This notebook demonstrates how BioThings Explorer can be used to answer the following query:

         "Finding Marketed Drugs that Might Treat an Unknown Syndrome by Perturbing the Disease Mechanism Pathway"

This query corresponds to Tidbit 4 which was formulated as a demonstration of the NCATS Translator program.

Background of BTE: BioThings Explorer can answer two classes of queries -- "EXPLAIN" and "PREDICT". EXPLAIN queries are described in EXPLAIN_demo.ipynb, and PREDICT queries are described in PREDICT_demo.ipynb. Here, we describe PREDICT queries and how to use BioThings Explorer to execute them. A more detailed overview of the BioThings Explorer systems is provided in these slides.

Background of TIDBIT 04:

A five-year-old patient was brought to the emergency room with recurrent polymicrobial lung infections, only 29% small airway function and was unresponsive to antibiotics.

The patient’s medical records included a genetics report from age 1, which showed a 1p34.1 chromosomal duplication encompassing 1.9 Mb, including the PRDX1 gene, which encodes Peroxiredoxin 1. The gene has been linked to airway disease in both rats and humans, and is known to act as an agonist of toll-like receptor 4 (TLR4), a pro-inflammatory receptor. In addition, two patients at another clinic were found to have 1p34.1 duplications:

  1. One patient with a duplication including PRDX1 died with similar phenotypes
  2. One patient with a duplication that did NOT include PRDX1 showed no airway disease phenotype While recurrent lung infections are typically treated with antibiotics, this patient was unresponsive to standard treatments. The patient’s earlier genetics report and data from other patients with similar duplications gave the physician evidence that PRDX1 may play a role in the disease, but no treatments directly related to the gene were known. With this information in mind, the physician asked a researcher familiar with Translator to try to find possible treatments for this patient.

How Might Translator Help? The patient’s duplication of the 1p34.1 region of chromosome 1 gave Translator researchers a good place to start. Since PRDX1 is an agonist of TLR4, the duplication of the PRDX1 gene likely causes overexpression of PRDX1, which could lead to overactivity of both of the gene products. The researcher decided to try to find drugs that could be used to reduce the activity of those two proteins. An exhaustive search of chemical databases and PubMed to find safe drug options could take days to weeks.

For a known genetic mutation, can Translator be used to quickly find existing modulators to compensate for the dysfunctional gene product?

Step 1: Find representation of "PRDX1" in BTE

In this step, BioThings Explorer translates our query string "PRDX1" into BioThings objects, which contain mappings to many common identifiers. Generally, the top result returned by the Hint module will be the correct item, but you should confirm that using the identifiers shown.

Search terms can correspond to any child of BiologicalEntity from the Biolink Model, including DiseaseOrPhenotypicFeature (e.g., "lupus"), ChemicalSubstance (e.g., "acetaminophen"), Gene (e.g., "CDK2"), BiologicalProcess (e.g., "T cell differentiation"), and Pathway (e.g., "Citric acid cycle").





In [1]:



    


from biothings_explorer.hint import Hint
ht = Hint()
prdx1 = ht.query("PRDX1")['Gene'][0]

prdx1



    


















    
Out[1]:








{'entrez': '5052',
 'name': 'peroxiredoxin 1',
 'symbol': 'PRDX1',
 'taxonomy': 9606,
 'umls': 'C1418879',
 'uniprot': 'Q06830',
 'hgnc': '9352',
 'ensembl': 'ENSG00000117450',
 'display': 'entrez(5052) name(peroxiredoxin 1) symbol(PRDX1) taxonomy(9606) umls(C1418879) uniprot(Q06830) hgnc(9352) ensembl(ENSG00000117450) ',
 'type': 'Gene',
 'primary': {'identifier': 'entrez', 'cls': 'Gene', 'value': '5052'}}

Step 2: Find drugs that are associated with genes which are associated with PRDX1

In this section, we find all paths in the knowledge graph that connect PRDX1 to any entity that is a chemical compound. To do that, we will use FindConnection. This class is a convenient wrapper around two advanced functions for query path planning and query path execution. More advanced features for both query path planning and query path execution are in development and will be documented in the coming months.

The parameters for FindConnection are described below:





In [2]:



    


from biothings_explorer.user_query_dispatcher import FindConnection

fc = FindConnection(input_obj=prdx1, output_obj='ChemicalSubstance', intermediate_nodes=['Gene'])
fc.connect(verbose=True)



    


















    






==========
========== QUERY PARAMETER SUMMARY ==========
==========

BTE will find paths that join 'PRDX1' and 'ChemicalSubstance'. Paths will have 1 intermediate node.

Intermediate node #1 will have these type constraints: Gene




========== QUERY #1 -- fetch all Gene entities linked to PRDX1 ==========
==========

==== Step #1: Query path planning ====

Because PRDX1 is of type 'Gene', BTE will query our meta-KG for APIs that can take 'Gene' as input and 'Gene' as output

BTE found 3 apis:

API 1. mygene.info(3 API calls)
API 2. semmedgene(11 API calls)
API 3. biolink_geneinteraction(1 API call)


==== Step #2: Query path execution ====
NOTE: API requests are dispatched in parallel, so the list of APIs below is ordered by query time.

API 1.1: http://mygene.info/v3/query (POST "q=5052&scopes=entrezgene&fields=pantherdb.ortholog&species=human&size=100")
API 1.2: http://mygene.info/v3/query (POST "q=ENSG00000117450&scopes=pantherdb.ortholog.Ensembl&fields=entrezgene&species=human&size=100")
API 1.3: http://mygene.info/v3/query (POST "q=9352&scopes=pantherdb.ortholog.HGNC&fields=entrezgene&species=human&size=100")
API 2.2: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=affects.protein.umls&fields=umls&species=human&size=100")
API 2.8: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=interacts_with.gene.umls&fields=umls&species=human&size=100")
API 2.1: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=affects.gene.umls&fields=umls&species=human&size=100")
API 2.9: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=interacts_with.protein.umls&fields=umls&species=human&size=100")
API 2.10: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=stimulates.protein.umls&fields=umls&species=human&size=100")
API 2.11: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=umls&fields=disrupts.protein,associated_with.gene,interacts_with.protein,stimulates.protein,inhibits.protein,disrupts.gene,affects.protein,interacts_with.gene,inhibits.gene,affects.gene&species=human&size=100")
API 2.5: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=disrupts.protein.umls&fields=umls&species=human&size=100")
API 2.4: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=disrupts.gene.umls&fields=umls&species=human&size=100")
API 2.7: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=inhibits.protein.umls&fields=umls&species=human&size=100")
API 2.6: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=inhibits.gene.umls&fields=umls&species=human&size=100")
API 2.3: https://pending.biothings.io/semmedgene/query (POST "q=C1418879&scopes=associated_with.gene.umls&fields=umls&species=human&size=100")
API 3.1: https://api.monarchinitiative.org/api/bioentity/gene/NCBIGene:5052/interactions?rows=100


==== Step #3: Output normalization ====

API 3.1 biolink_geneinteraction: 100 hits
API 1.1 mygene.info: 16 hits
API 1.2 mygene.info: No hits
API 1.3 mygene.info: 1 hits
API 2.1 semmedgene: No hits
API 2.2 semmedgene: No hits
API 2.3 semmedgene: No hits
API 2.4 semmedgene: No hits
API 2.5 semmedgene: No hits
API 2.6 semmedgene: 11 hits
API 2.7 semmedgene: No hits
API 2.8 semmedgene: 38 hits
API 2.9 semmedgene: No hits
API 2.10 semmedgene: No hits
API 2.11 semmedgene: 85 hits

After id-to-object translation, BTE retrieved 218 unique objects.


========== QUERY #2.1 -- fetch all ChemicalSubstance entities linked to Gene entites ==========
==========

==== Step #1: Query path planning ====

Because None is of type 'Gene', BTE will query our meta-KG for APIs that can take 'Gene' as input and 'ChemicalSubstance' as output

BTE found 5 apis:

API 1. mychem.info(3 API calls)
API 2. dgidb_gene2chemical(146 API calls)
API 3. opentarget(162 API calls)
API 4. robokop_gene2chemical(146 API calls)
API 5. semmedgene(1 API call)


==== Step #2: Query path execution ====
NOTE: API requests are dispatched in parallel, so the list of APIs below is ordered by query time.

API 3.10: http://www.dgidb.org/api/v2/interactions.json?genes=PPHLN1
API 3.1: http://www.dgidb.org/api/v2/interactions.json?genes=ACY1
API 3.12: http://www.dgidb.org/api/v2/interactions.json?genes=TP63
API 3.17: http://www.dgidb.org/api/v2/interactions.json?genes=VIRMA
API 3.15: http://www.dgidb.org/api/v2/interactions.json?genes=DCPS
API 3.37: http://www.dgidb.org/api/v2/interactions.json?genes=BTRC
API 3.58: http://www.dgidb.org/api/v2/interactions.json?genes=CPLX2
dgidb_gene2chemical failed
API 3.11: http://www.dgidb.org/api/v2/interactions.json?genes=CRY1
API 3.35: http://www.dgidb.org/api/v2/interactions.json?genes=TLR4
dgidb_gene2chemical failed
API 3.7: http://www.dgidb.org/api/v2/interactions.json?genes=CALM1
API 3.44: http://www.dgidb.org/api/v2/interactions.json?genes=APEX1
API 3.31: http://www.dgidb.org/api/v2/interactions.json?genes=OTUB1
API 3.47: http://www.dgidb.org/api/v2/interactions.json?genes=DNPH1
API 3.19: http://www.dgidb.org/api/v2/interactions.json?genes=PHB
API 3.5: http://www.dgidb.org/api/v2/interactions.json?genes=DAB2
API 3.30: http://www.dgidb.org/api/v2/interactions.json?genes=BRCA1
API 3.24: http://www.dgidb.org/api/v2/interactions.json?genes=COX6B1
API 2.2: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000051382&datasource=chembl&size=15&fields=drug
API 2.1: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000036257&datasource=chembl&size=15&fields=drug
API 3.20: http://www.dgidb.org/api/v2/interactions.json?genes=ISG15
API 3.16: http://www.dgidb.org/api/v2/interactions.json?genes=SOD2
API 3.39: http://www.dgidb.org/api/v2/interactions.json?genes=RECQL4
API 3.40: http://www.dgidb.org/api/v2/interactions.json?genes=SOD1
API 3.2: http://www.dgidb.org/api/v2/interactions.json?genes=PRTN3
API 3.8: http://www.dgidb.org/api/v2/interactions.json?genes=PTPN1
API 3.13: http://www.dgidb.org/api/v2/interactions.json?genes=PBK
dgidb_gene2chemical failed
API 2.7: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000108094&datasource=chembl&size=15&fields=drug
API 3.28: http://www.dgidb.org/api/v2/interactions.json?genes=SH3BGRL2
API 3.53: http://www.dgidb.org/api/v2/interactions.json?genes=CDK9
API 3.38: http://www.dgidb.org/api/v2/interactions.json?genes=LAP3
API 2.4: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000228978&datasource=chembl&size=15&fields=drug
API 3.50: http://www.dgidb.org/api/v2/interactions.json?genes=CREB1
API 3.32: http://www.dgidb.org/api/v2/interactions.json?genes=PTEN
API 3.45: http://www.dgidb.org/api/v2/interactions.json?genes=GABPA
API 3.29: http://www.dgidb.org/api/v2/interactions.json?genes=CLEC4G
API 3.43: http://www.dgidb.org/api/v2/interactions.json?genes=SYK
API 3.42: http://www.dgidb.org/api/v2/interactions.json?genes=PTPRC
API 3.49: http://www.dgidb.org/api/v2/interactions.json?genes=RPA2
API 2.5: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000276230&datasource=chembl&size=15&fields=drug
API 3.51: http://www.dgidb.org/api/v2/interactions.json?genes=RBMS3
API 3.48: http://www.dgidb.org/api/v2/interactions.json?genes=NTRK1
API 2.8: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000056097&datasource=chembl&size=15&fields=drug
API 2.10: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000158555&datasource=chembl&size=15&fields=drug
API 2.11: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000039068&datasource=chembl&size=15&fields=drug
API 3.14: http://www.dgidb.org/api/v2/interactions.json?genes=CFTR
API 3.22: http://www.dgidb.org/api/v2/interactions.json?genes=CUL4B
API 3.54: http://www.dgidb.org/api/v2/interactions.json?genes=FERMT3
API 3.36: http://www.dgidb.org/api/v2/interactions.json?genes=CALB2
dgidb_gene2chemical failed
dgidb_gene2chemical failed
API 3.93: http://www.dgidb.org/api/v2/interactions.json?genes=PRKDC
API 3.9: http://www.dgidb.org/api/v2/interactions.json?genes=ZFR
API 3.33: http://www.dgidb.org/api/v2/interactions.json?genes=MST1
API 3.18: http://www.dgidb.org/api/v2/interactions.json?genes=TERF1
API 3.4: http://www.dgidb.org/api/v2/interactions.json?genes=EEF1A1
API 3.46: http://www.dgidb.org/api/v2/interactions.json?genes=PPP2R1B
API 2.13: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000146648&datasource=chembl&size=15&fields=drug
API 3.25: http://www.dgidb.org/api/v2/interactions.json?genes=UCHL5
API 3.26: http://www.dgidb.org/api/v2/interactions.json?genes=RC3H1
API 3.6: http://www.dgidb.org/api/v2/interactions.json?genes=PRRX1
API 3.52: http://www.dgidb.org/api/v2/interactions.json?genes=DCUN1D1
API 2.18: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000167193&datasource=chembl&size=15&fields=drug
API 3.27: http://www.dgidb.org/api/v2/interactions.json?genes=YAP1
API 2.16: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000023191&datasource=chembl&size=15&fields=drug
API 3.57: http://www.dgidb.org/api/v2/interactions.json?genes=FYN
API 2.15: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000157326&datasource=chembl&size=15&fields=drug
API 3.23: http://www.dgidb.org/api/v2/interactions.json?genes=CFL1
API 3.21: http://www.dgidb.org/api/v2/interactions.json?genes=SRXN1
API 3.96: http://www.dgidb.org/api/v2/interactions.json?genes=HECTD1
API 2.22: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000142168&datasource=chembl&size=15&fields=drug
API 3.41: http://www.dgidb.org/api/v2/interactions.json?genes=COPS6
API 3.90: http://www.dgidb.org/api/v2/interactions.json?genes=COX17
API 3.68: http://www.dgidb.org/api/v2/interactions.json?genes=UBE2M
API 3.88: http://www.dgidb.org/api/v2/interactions.json?genes=MEPCE
API 3.77: http://www.dgidb.org/api/v2/interactions.json?genes=VRK3
API 3.34: http://www.dgidb.org/api/v2/interactions.json?genes=LGALS3
API 3.70: http://www.dgidb.org/api/v2/interactions.json?genes=CTSD
API 3.81: http://www.dgidb.org/api/v2/interactions.json?genes=CDC42
API 3.100: http://www.dgidb.org/api/v2/interactions.json?genes=ETS1
API 2.21: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000174231&datasource=chembl&size=15&fields=drug
API 2.3: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000145715&datasource=chembl&size=15&fields=drug
API 3.97: http://www.dgidb.org/api/v2/interactions.json?genes=PPP2R1A
API 3.99: http://www.dgidb.org/api/v2/interactions.json?genes=SCCPDH
API 2.17: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000145388&datasource=chembl&size=15&fields=drug
API 2.23: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000178691&datasource=chembl&size=15&fields=drug
API 2.28: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000094631&datasource=chembl&size=15&fields=drug
API 3.82: http://www.dgidb.org/api/v2/interactions.json?genes=CDH1
API 2.24: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSGALG00000010243&datasource=chembl&size=15&fields=drug
API 3.87: http://www.dgidb.org/api/v2/interactions.json?genes=RNF123
API 3.62: http://www.dgidb.org/api/v2/interactions.json?genes=RNF144A
API 3.72: http://www.dgidb.org/api/v2/interactions.json?genes=WTAP
API 3.78: http://www.dgidb.org/api/v2/interactions.json?genes=PRKCZ
API 2.20: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000143653&datasource=chembl&size=15&fields=drug
API 3.75: http://www.dgidb.org/api/v2/interactions.json?genes=DAZAP1
API 3.92: http://www.dgidb.org/api/v2/interactions.json?genes=CUL3
API 3.84: http://www.dgidb.org/api/v2/interactions.json?genes=ANAPC15
API 3.85: http://www.dgidb.org/api/v2/interactions.json?genes=PRDX6
API 3.74: http://www.dgidb.org/api/v2/interactions.json?genes=ERVW-4
API 2.33: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000228321&datasource=chembl&size=15&fields=drug
API 2.34: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000115317&datasource=chembl&size=15&fields=drug
API 3.63: http://www.dgidb.org/api/v2/interactions.json?genes=PRDX2
API 3.98: http://www.dgidb.org/api/v2/interactions.json?genes=PIDD1
API 3.61: http://www.dgidb.org/api/v2/interactions.json?genes=HTRA2
API 3.95: http://www.dgidb.org/api/v2/interactions.json?genes=CDC73
API 3.59: http://www.dgidb.org/api/v2/interactions.json?genes=RPA1
API 3.103: http://www.dgidb.org/api/v2/interactions.json?genes=RIOK1
API 3.86: http://www.dgidb.org/api/v2/interactions.json?genes=GAPDH
API 3.104: http://www.dgidb.org/api/v2/interactions.json?genes=MTTP
API 2.26: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000002016&datasource=chembl&size=15&fields=drug
API 2.14: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000106399&datasource=chembl&size=15&fields=drug
API 3.76: http://www.dgidb.org/api/v2/interactions.json?genes=CDC37
API 2.6: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000110063&datasource=chembl&size=15&fields=drug
API 2.31: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000127445&datasource=chembl&size=15&fields=drug
API 2.30: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000116132&datasource=chembl&size=15&fields=drug
API 2.29: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000137713&datasource=chembl&size=15&fields=drug
API 2.25: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000149781&datasource=chembl&size=15&fields=drug
API 2.32: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000121879&datasource=chembl&size=15&fields=drug
API 3.64: http://www.dgidb.org/api/v2/interactions.json?genes=OBSL1
API 2.9: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000131981&datasource=chembl&size=15&fields=drug
API 3.3: http://www.dgidb.org/api/v2/interactions.json?genes=PIK3CA
API 3.105: http://www.dgidb.org/api/v2/interactions.json?genes=RAD23A
API 3.79: http://www.dgidb.org/api/v2/interactions.json?genes=CRK
API 2.12: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000136810&datasource=chembl&size=15&fields=drug
API 3.71: http://www.dgidb.org/api/v2/interactions.json?genes=ZFP36L2
API 2.35: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000284807&datasource=chembl&size=15&fields=drug
API 3.108: http://www.dgidb.org/api/v2/interactions.json?genes=AAR2
API 3.91: http://www.dgidb.org/api/v2/interactions.json?genes=CYLD
API 2.44: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000010810&datasource=chembl&size=15&fields=drug
API 3.80: http://www.dgidb.org/api/v2/interactions.json?genes=PDP1
API 3.65: http://www.dgidb.org/api/v2/interactions.json?genes=PPT1
API 2.36: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000117322&datasource=chembl&size=15&fields=drug
API 3.89: http://www.dgidb.org/api/v2/interactions.json?genes=SESN2
API 3.107: http://www.dgidb.org/api/v2/interactions.json?genes=METTL14
API 2.40: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000112667&datasource=chembl&size=15&fields=drug
API 2.39: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000123374&datasource=chembl&size=15&fields=drug
API 3.56: http://www.dgidb.org/api/v2/interactions.json?genes=TRIM4
API 3.112: http://www.dgidb.org/api/v2/interactions.json?genes=JTB
API 3.67: http://www.dgidb.org/api/v2/interactions.json?genes=U2AF2
API 2.42: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000262418&datasource=chembl&size=15&fields=drug
API 3.109: http://www.dgidb.org/api/v2/interactions.json?genes=KMT2A
API 2.43: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000179262&datasource=chembl&size=15&fields=drug
API 3.111: http://www.dgidb.org/api/v2/interactions.json?genes=PRDX3
API 3.114: http://www.dgidb.org/api/v2/interactions.json?genes=RPA3
API 3.66: http://www.dgidb.org/api/v2/interactions.json?genes=AGO4
API 3.60: http://www.dgidb.org/api/v2/interactions.json?genes=CAT
API 2.38: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000139842&datasource=chembl&size=15&fields=drug
API 2.37: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000081237&datasource=chembl&size=15&fields=drug
API 2.45: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000134371&datasource=chembl&size=15&fields=drug
API 2.46: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000164093&datasource=chembl&size=15&fields=drug
API 2.47: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000080546&datasource=chembl&size=15&fields=drug
API 2.41: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000172757&datasource=chembl&size=15&fields=drug
API 3.116: http://www.dgidb.org/api/v2/interactions.json?genes=RAB4B
API 3.110: http://www.dgidb.org/api/v2/interactions.json?genes=VEGFA
API 3.94: http://www.dgidb.org/api/v2/interactions.json?genes=PRPF8
API 3.83: http://www.dgidb.org/api/v2/interactions.json?genes=CUL7
API 3.55: http://www.dgidb.org/api/v2/interactions.json?genes=PRDX4
API 2.49: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000198668&datasource=chembl&size=15&fields=drug
API 2.55: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000206439&datasource=chembl&size=15&fields=drug
API 2.50: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000177595&datasource=chembl&size=15&fields=drug
API 5.1: https://pending.biothings.io/semmedgene/query (POST "q=C1709127,C1539098,C1825045,C1335607,C3642141,C1708291,C1705691,C1412825,C0036773,C1427363,C1425940,C1419277,C1332102,C0031678,C1825463,C0031727,C2700100,C1426328,C1419243,C1367578,C2984529,C0059256,C1826784,C1826843,C1335208,C3272447,C0027021,C0086661,C1425509,C1427252,C1456380,C1418696,C1420306,C1424590,C1822651,C1420307,C1424868,C0527356,C1413696,C1332812,C1419619,C1709820,C1335262,C1413724,C1336636,C1824317,C1332813,C1423806,C3539596,C1424792,C1439337,C0017822,C0812303,C1414270,C1414905,C0079050,C0071827,C0056467,C1418582,C1413081,C1424135,C1826505,C0669365,C1418837,C1424145,C0812252,C1705581,C2698689,C0017360,C1823619,C1705387,C1333202,C1424518,C1424915,C1421047,C1422009,C1704928,C1419236,C1707161,C1336690,C1419620,C1413290,C1423579,C4285071,C1426741,C0312359,C1425683,C3714973,C1426197,C1705633,C0079427,C1418928,C0164786,C1416831,C1539559,C1413614,C1825621,C1332805,C1418854,C1332809,C1706351,C1335243,C1825689,C1332733,C1419211,C1418270,C0672553,C1709439,C1427633,C0919528,C1332722,C0812201,C1705981,C1538595,C1707152,C0694888,C1332811,C1823127,C1413365,C1424323,C1421986,C0376571,C1335213,C1425522,C0812228,C1705518,C0969119,C0248813,C1413633,C1705047,C1414968,C1413355,C1427952,C1334294,C0287531,C0010642,C0073337,C1424673,C1332810,C0140145,C1418818,C1705442,C1335267,C2681660,C1826565,C0138965,C1412851,C1336604,C0812246,C1427739,C1418881,C1826328,C1825553,C0024750,C1417377,C1708031,C1335892,C1413671,C0085114,C0022959,C1418880,C1705325,C1332695,C1539228,C1418882,C1335285,C1418596,C1426950,C1421999,C3148432,C1335281,C1413850,C1826417,C0919487,C1539902,C1825792,C1414313,C0010531,C0282625,C1413912,C1413138,C1421289,C0033681,C1413826,C1824894,C1539128,C1427105,C1420667,C1332659,C1335212,C1842840,C0074147,C1427424,C1427896,C1705997,C1335248,C1412173,C1333895,C0029073,C1419618,C1413702,C3147237,C0694872,C0007367,C1366537&scopes=umls&fields=interacts_with_reverse.chemical_substance,associated_with.chemical_substance,affects_reverse.chemical_substance,affects.chemical_substance,associated_with_reverse.chemical_substance,interacts_with.chemical_substance&species=human&size=100")
API 3.118: http://www.dgidb.org/api/v2/interactions.json?genes=CCNB1
API 2.19: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000131043&datasource=chembl&size=15&fields=drug
API 2.51: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000186834&datasource=chembl&size=15&fields=drug
API 3.73: http://www.dgidb.org/api/v2/interactions.json?genes=CR2
API 3.119: http://www.dgidb.org/api/v2/interactions.json?genes=SUZ12
API 3.117: http://www.dgidb.org/api/v2/interactions.json?genes=EIF4A3
API 3.120: http://www.dgidb.org/api/v2/interactions.json?genes=RASA1
API 3.122: http://www.dgidb.org/api/v2/interactions.json?genes=SESN1
API 3.123: http://www.dgidb.org/api/v2/interactions.json?genes=GDPD5
API 3.121: http://www.dgidb.org/api/v2/interactions.json?genes=RNH1
API 2.52: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000146834&datasource=chembl&size=15&fields=drug
API 2.53: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000158290&datasource=chembl&size=15&fields=drug
API 3.125: http://www.dgidb.org/api/v2/interactions.json?genes=TXN
API 2.54: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000167770&datasource=chembl&size=15&fields=drug
API 3.69: http://www.dgidb.org/api/v2/interactions.json?genes=AR
API 2.56: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000173531&datasource=chembl&size=15&fields=drug
API 2.61: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000112096&datasource=chembl&size=15&fields=drug
API 3.126: http://www.dgidb.org/api/v2/interactions.json?genes=SLC38A1
API 2.58: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000105568&datasource=chembl&size=15&fields=drug
API 3.128: http://www.dgidb.org/api/v2/interactions.json?genes=TDGF1
API 2.64: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000285441&datasource=chembl&size=15&fields=drug
API 3.130: http://www.dgidb.org/api/v2/interactions.json?genes=PEBP1
API 3.129: http://www.dgidb.org/api/v2/interactions.json?genes=LARP7
API 2.60: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000063244&datasource=chembl&size=15&fields=drug
API 2.66: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000142208&datasource=chembl&size=15&fields=drug
API 3.131: http://www.dgidb.org/api/v2/interactions.json?genes=CUL1
API 3.132: http://www.dgidb.org/api/v2/interactions.json?genes=CUL4A
API 2.62: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000143543&datasource=chembl&size=15&fields=drug
API 2.68: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000204490&datasource=chembl&size=15&fields=drug
API 3.133: http://www.dgidb.org/api/v2/interactions.json?genes=CUL5
API 2.27: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000274442&datasource=chembl&size=15&fields=drug
API 2.70: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000284792&datasource=chembl&size=15&fields=drug
API 3.134: http://www.dgidb.org/api/v2/interactions.json?genes=MTRNR2L1
API 3.135: http://www.dgidb.org/api/v2/interactions.json?genes=CUL2
API 3.137: http://www.dgidb.org/api/v2/interactions.json?genes=TRBV20OR9-2
API 2.67: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000241186&datasource=chembl&size=15&fields=drug
API 3.136: http://www.dgidb.org/api/v2/interactions.json?genes=NF2
API 2.69: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000044090&datasource=chembl&size=15&fields=drug
API 3.140: http://www.dgidb.org/api/v2/interactions.json?genes=PRKN
API 2.72: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000123131&datasource=chembl&size=15&fields=drug
API 2.71: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000151692&datasource=chembl&size=15&fields=drug
API 3.141: http://www.dgidb.org/api/v2/interactions.json?genes=HEXIM1
API 2.73: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000243989&datasource=chembl&size=15&fields=drug
API 2.48: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000126432&datasource=chembl&size=15&fields=drug
API 2.63: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000136997&datasource=chembl&size=15&fields=drug
API 3.142: http://www.dgidb.org/api/v2/interactions.json?genes=PRDX5
API 3.143: http://www.dgidb.org/api/v2/interactions.json?genes=COPS5
API 2.57: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000145920&datasource=chembl&size=15&fields=drug
API 3.145: http://www.dgidb.org/api/v2/interactions.json?genes=PITX2
API 3.144: http://www.dgidb.org/api/v2/interactions.json?genes=RAD52
API 3.138: http://www.dgidb.org/api/v2/interactions.json?genes=MYC
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
API 3.146: http://www.dgidb.org/api/v2/interactions.json?genes=PPP2R5D
robokop_gene2chemical failed
API 2.59: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000168090&datasource=chembl&size=15&fields=drug
API 3.124: http://www.dgidb.org/api/v2/interactions.json?genes=CDK2
API 3.139: http://www.dgidb.org/api/v2/interactions.json?genes=PIK3CB
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
API 2.76: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000282830&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
API 2.65: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000117984&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
opentarget failed
opentarget failed
API 2.84: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000008405&datasource=chembl&size=15&fields=drug
API 2.75: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000187608&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
API 2.77: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000196396&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
API 2.80: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000166266&datasource=chembl&size=15&fields=drug
API 2.83: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000083799&datasource=chembl&size=15&fields=drug
API 2.79: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000169083&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
API 2.86: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000116750&datasource=chembl&size=15&fields=drug
API 2.81: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000089220&datasource=chembl&size=15&fields=drug
opentarget failed
robokop_gene2chemical failed
API 2.85: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000136807&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
opentarget failed
API 2.82: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000131238&datasource=chembl&size=15&fields=drug
API 2.87: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000117748&datasource=chembl&size=15&fields=drug
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
robokop_gene2chemical failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
opentarget failed
opentarget failed
robokop_gene2chemical failed
opentarget failed
API 2.88: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000117592&datasource=chembl&size=15&fields=drug
API 2.115: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000121691&datasource=chembl&size=15&fields=drug
opentarget failed
opentarget failed
API 2.148: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000136869&datasource=chembl&size=15&fields=drug
API 2.162: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000070831&datasource=chembl&size=15&fields=drug
API 2.78: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSRNOG00000017695&datasource=chembl&size=15&fields=drug
API 2.99: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000138823&datasource=chembl&size=15&fields=drug
API 2.114: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000134954&datasource=chembl&size=15&fields=drug
API 2.116: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000160957&datasource=chembl&size=15&fields=drug
API 2.126: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000100823&datasource=chembl&size=15&fields=drug
API 2.131: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000001626&datasource=chembl&size=15&fields=drug
API 2.129: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000185345&datasource=chembl&size=15&fields=drug
API 2.107: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000012048&datasource=chembl&size=15&fields=drug
API 2.74: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000198400&datasource=chembl&size=15&fields=drug
API 2.132: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000092148&datasource=chembl&size=15&fields=drug
API 2.127: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000165025&datasource=chembl&size=15&fields=drug
API 2.147: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000196415&datasource=chembl&size=15&fields=drug
API 2.128: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000118260&datasource=chembl&size=15&fields=drug
API 2.160: https://platform-api.opentargets.io/v3/platform/public/evidence/filter?target=ENSG00000146833&datasource=chembl&size=15&fields=drug
API 3.127: http://www.dgidb.org/api/v2/interactions.json?genes=EGFR
API 4.1: https://robokop.renci.org/api/simple/expand/gene/HGNC:17277/chemical_substance/
API 4.3: https://robokop.renci.org/api/simple/expand/gene/HGNC:18656/chemical_substance/
API 4.5: https://robokop.renci.org/api/simple/expand/gene/HGNC:9642/chemical_substance/
API 4.2: https://robokop.renci.org/api/simple/expand/gene/HGNC:1884/chemical_substance/
API 1.1: http://mychem.info/v1/query (POST "q=ACY1,PIK3CA,EEF1A1,CALM1,CRY1,TP63,CFTR,VIRMA,TERF1,PHB,COX6B1,UCHL5,BRCA1,MST1,PTEN,TLR4,SOD1,COPS6,PTPRC,SYK,APEX1,GABPA,DNPH1,NTRK1,RBMS3,DCUN1D1,CDK9,FERMT3,FYN,CAT,HTRA2,PRDX2,OBSL1,PPT1,AGO4,U2AF2,UBE2M,AR,CR2,DAZAP1,CDC37,PRKCZ,CDC42,CDH1,ANAPC15,JTB,PRDX6,MEPCE,CYLD,CUL3,PRKDC,CDC73,AKT1,HDAC6,RIOK1,TNF,METTL14,AAR2,VEGFA,DHRS4,RAB4B,RASA1,SESN1,CDK2,EGFR,TDGF1,PEBP1,MTRNR2L1,TRBV20OR9-2,MYC,HEXIM1,PRDX5,HECTD1,RAD52,PRTN3,DAB2,PRRX1,PTPN1,ZFR,PPHLN1,PBK,DCPS,SOD2,ISG15,SRXN1,CUL4B,CFL1,RC3H1,YAP1,SH3BGRL2,LGALS3,OTUB1,CALB2,BTRC,LAP3,RECQL4,PPP2R1B,RPA2,CREB1,CPLX2,PRDX4,TRIM4,RPA1,RNF144A,ERVW-4,CTSD,ZFP36L2,WTAP,VRK3,CRK,PDP1,CUL7,GAPDH,RNF123,SESN2,COX17,PRPF8,PPP2R1A,PIDD1,SCCPDH,ETS1,MTTP,RAD23A,KMT2A,PRDX3,RPA3,PIN1,GDPD5,EIF4A3,CCNB1,SUZ12,RNH1,TXN,SLC38A1,LARP7,CUL1,CUL4A,CUL5,CUL2,NF2,PIK3CB,PRKN,COPS5,CLEC4G,PITX2,PPP2R5D&scopes=drugbank.enzymes.gene_name&fields=drugbank.id&species=human&size=100")
API 4.4: https://robokop.renci.org/api/simple/expand/gene/HGNC:9588/chemical_substance/
API 4.7: https://robokop.renci.org/api/simple/expand/gene/HGNC:10291/chemical_substance/
API 4.10: https://robokop.renci.org/api/simple/expand/gene/HGNC:18184/chemical_substance/
API 4.13: https://robokop.renci.org/api/simple/expand/gene/HGNC:29330/chemical_substance/
API 4.6: https://robokop.renci.org/api/simple/expand/gene/HGNC:12435/chemical_substance/
API 4.15: https://robokop.renci.org/api/simple/expand/gene/HGNC:16132/chemical_substance/
API 4.12: https://robokop.renci.org/api/simple/expand/gene/HGNC:3189/chemical_substance/
API 4.8: https://robokop.renci.org/api/simple/expand/gene/HGNC:8975/chemical_substance/
API 4.14: https://robokop.renci.org/api/simple/expand/gene/HGNC:9302/chemical_substance/
API 4.9: https://robokop.renci.org/api/simple/expand/gene/HGNC:12680/chemical_substance/
API 4.11: https://robokop.renci.org/api/simple/expand/gene/HGNC:11850/chemical_substance/
API 4.17: https://robokop.renci.org/api/simple/expand/gene/HGNC:9495/chemical_substance/
API 4.18: https://robokop.renci.org/api/simple/expand/gene/HGNC:1735/chemical_substance/
API 1.3: http://mychem.info/v1/query (POST "q=ACY1,PIK3CA,EEF1A1,CALM1,CRY1,TP63,CFTR,VIRMA,TERF1,PHB,COX6B1,UCHL5,BRCA1,MST1,PTEN,TLR4,SOD1,COPS6,PTPRC,SYK,APEX1,GABPA,DNPH1,NTRK1,RBMS3,DCUN1D1,CDK9,FERMT3,FYN,CAT,HTRA2,PRDX2,OBSL1,PPT1,AGO4,U2AF2,UBE2M,AR,CR2,DAZAP1,CDC37,PRKCZ,CDC42,CDH1,ANAPC15,JTB,PRDX6,MEPCE,CYLD,CUL3,PRKDC,CDC73,AKT1,HDAC6,RIOK1,TNF,METTL14,AAR2,VEGFA,DHRS4,RAB4B,RASA1,SESN1,CDK2,EGFR,TDGF1,PEBP1,MTRNR2L1,TRBV20OR9-2,MYC,HEXIM1,PRDX5,HECTD1,RAD52,PRTN3,DAB2,PRRX1,PTPN1,ZFR,PPHLN1,PBK,DCPS,SOD2,ISG15,SRXN1,CUL4B,CFL1,RC3H1,YAP1,SH3BGRL2,LGALS3,OTUB1,CALB2,BTRC,LAP3,RECQL4,PPP2R1B,RPA2,CREB1,CPLX2,PRDX4,TRIM4,RPA1,RNF144A,ERVW-4,CTSD,ZFP36L2,WTAP,VRK3,CRK,PDP1,CUL7,GAPDH,RNF123,SESN2,COX17,PRPF8,PPP2R1A,PIDD1,SCCPDH,ETS1,MTTP,RAD23A,KMT2A,PRDX3,RPA3,PIN1,GDPD5,EIF4A3,CCNB1,SUZ12,RNH1,TXN,SLC38A1,LARP7,CUL1,CUL4A,CUL5,CUL2,NF2,PIK3CB,PRKN,COPS5,CLEC4G,PITX2,PPP2R5D&scopes=drugcentral.bioactivity.uniprot.gene_symbol&fields=chembl.molecule_chembl_id&species=human&size=100")
API 4.16: https://robokop.renci.org/api/simple/expand/gene/HGNC:2345/chemical_substance/
API 4.21: https://robokop.renci.org/api/simple/expand/gene/HGNC:2384/chemical_substance/
API 1.2: http://mychem.info/v1/query (POST "q=ACY1,PIK3CA,EEF1A1,CALM1,CRY1,TP63,CFTR,VIRMA,TERF1,PHB,COX6B1,UCHL5,BRCA1,MST1,PTEN,TLR4,SOD1,COPS6,PTPRC,SYK,APEX1,GABPA,DNPH1,NTRK1,RBMS3,DCUN1D1,CDK9,FERMT3,FYN,CAT,HTRA2,PRDX2,OBSL1,PPT1,AGO4,U2AF2,UBE2M,AR,CR2,DAZAP1,CDC37,PRKCZ,CDC42,CDH1,ANAPC15,JTB,PRDX6,MEPCE,CYLD,CUL3,PRKDC,CDC73,AKT1,HDAC6,RIOK1,TNF,METTL14,AAR2,VEGFA,DHRS4,RAB4B,RASA1,SESN1,CDK2,EGFR,TDGF1,PEBP1,MTRNR2L1,TRBV20OR9-2,MYC,HEXIM1,PRDX5,HECTD1,RAD52,PRTN3,DAB2,PRRX1,PTPN1,ZFR,PPHLN1,PBK,DCPS,SOD2,ISG15,SRXN1,CUL4B,CFL1,RC3H1,YAP1,SH3BGRL2,LGALS3,OTUB1,CALB2,BTRC,LAP3,RECQL4,PPP2R1B,RPA2,CREB1,CPLX2,PRDX4,TRIM4,RPA1,RNF144A,ERVW-4,CTSD,ZFP36L2,WTAP,VRK3,CRK,PDP1,CUL7,GAPDH,RNF123,SESN2,COX17,PRPF8,PPP2R1A,PIDD1,SCCPDH,ETS1,MTTP,RAD23A,KMT2A,PRDX3,RPA3,PIN1,GDPD5,EIF4A3,CCNB1,SUZ12,RNH1,TXN,SLC38A1,LARP7,CUL1,CUL4A,CUL5,CUL2,NF2,PIK3CB,PRKN,COPS5,CLEC4G,PITX2,PPP2R5D&scopes=drugbank.targets.gene_name&fields=drugbank.id&species=human&size=100")
API 4.22: https://robokop.renci.org/api/simple/expand/gene/HGNC:9303/chemical_substance/
API 4.25: https://robokop.renci.org/api/simple/expand/gene/HGNC:2240/chemical_substance/
API 4.23: https://robokop.renci.org/api/simple/expand/gene/HGNC:12491/chemical_substance/
API 4.19: https://robokop.renci.org/api/simple/expand/gene/HGNC:587/chemical_substance/
API 4.29: https://robokop.renci.org/api/simple/expand/gene/HGNC:13447/chemical_substance/
API 4.30: https://robokop.renci.org/api/simple/expand/gene/HGNC:9812/chemical_substance/
API 4.31: https://robokop.renci.org/api/simple/expand/gene/HGNC:2551/chemical_substance/
API 4.32: https://robokop.renci.org/api/simple/expand/gene/HGNC:18996/chemical_substance/
API 4.26: https://robokop.renci.org/api/simple/expand/gene/HGNC:4037/chemical_substance/
API 4.28: https://robokop.renci.org/api/simple/expand/gene/HGNC:11180/chemical_substance/
API 4.24: https://robokop.renci.org/api/simple/expand/gene/HGNC:8912/chemical_substance/
API 4.27: https://robokop.renci.org/api/simple/expand/gene/HGNC:21024/chemical_substance/
API 4.20: https://robokop.renci.org/api/simple/expand/gene/HGNC:11892/chemical_substance/
API 4.33: https://robokop.renci.org/api/simple/expand/gene/HGNC:9354/chemical_substance/
API 4.34: https://robokop.renci.org/api/simple/expand/gene/HGNC:9355/chemical_substance/
API 4.37: https://robokop.renci.org/api/simple/expand/gene/HGNC:7773/chemical_substance/
API 4.35: https://robokop.renci.org/api/simple/expand/gene/HGNC:9142/chemical_substance/
API 4.36: https://robokop.renci.org/api/simple/expand/gene/HGNC:16846/chemical_substance/
API 4.41: https://robokop.renci.org/api/simple/expand/gene/HGNC:7380/chemical_substance/
API 4.39: https://robokop.renci.org/api/simple/expand/gene/HGNC:2362/chemical_substance/
API 4.45: https://robokop.renci.org/api/simple/expand/gene/HGNC:1442/chemical_substance/
API 4.42: https://robokop.renci.org/api/simple/expand/gene/HGNC:16985/chemical_substance/
API 4.43: https://robokop.renci.org/api/simple/expand/gene/HGNC:15567/chemical_substance/
API 4.38: https://robokop.renci.org/api/simple/expand/gene/HGNC:19678/chemical_substance/
API 4.46: https://robokop.renci.org/api/simple/expand/gene/HGNC:24275/chemical_substance/
API 4.40: https://robokop.renci.org/api/simple/expand/gene/HGNC:1435/chemical_substance/
API 4.47: https://robokop.renci.org/api/simple/expand/gene/HGNC:8031/chemical_substance/
API 4.44: https://robokop.renci.org/api/simple/expand/gene/HGNC:8630/chemical_substance/
API 4.53: https://robokop.renci.org/api/simple/expand/gene/HGNC:18424/chemical_substance/
API 4.50: https://robokop.renci.org/api/simple/expand/gene/HGNC:6201/chemical_substance/
API 4.52: https://robokop.renci.org/api/simple/expand/gene/HGNC:9782/chemical_substance/
API 4.49: https://robokop.renci.org/api/simple/expand/gene/HGNC:2264/chemical_substance/
API 4.54: https://robokop.renci.org/api/simple/expand/gene/HGNC:11701/chemical_substance/
API 4.59: https://robokop.renci.org/api/simple/expand/gene/HGNC:9312/chemical_substance/
API 4.58: https://robokop.renci.org/api/simple/expand/gene/HGNC:11179/chemical_substance/
API 4.51: https://robokop.renci.org/api/simple/expand/gene/HGNC:3488/chemical_substance/
API 4.48: https://robokop.renci.org/api/simple/expand/gene/HGNC:16753/chemical_substance/
API 4.64: https://robokop.renci.org/api/simple/expand/gene/HGNC:24500/chemical_substance/
API 4.61: https://robokop.renci.org/api/simple/expand/gene/HGNC:23151/chemical_substance/
API 4.63: https://robokop.renci.org/api/simple/expand/gene/HGNC:10074/chemical_substance/
API 4.57: https://robokop.renci.org/api/simple/expand/gene/HGNC:1144/chemical_substance/
API 4.60: https://robokop.renci.org/api/simple/expand/gene/HGNC:2683/chemical_substance/
API 4.55: https://robokop.renci.org/api/simple/expand/gene/HGNC:24912/chemical_substance/
API 4.68: https://robokop.renci.org/api/simple/expand/gene/HGNC:16783/chemical_substance/
API 4.62: https://robokop.renci.org/api/simple/expand/gene/HGNC:9413/chemical_substance/
API 4.56: https://robokop.renci.org/api/simple/expand/gene/HGNC:1748/chemical_substance/
API 4.78: https://robokop.renci.org/api/simple/expand/gene/HGNC:9871/chemical_substance/
API 4.66: https://robokop.renci.org/api/simple/expand/gene/HGNC:23156/chemical_substance/
API 4.65: https://robokop.renci.org/api/simple/expand/gene/HGNC:2584/chemical_substance/
API 4.74: https://robokop.renci.org/api/simple/expand/gene/HGNC:14064/chemical_substance/
API 4.75: https://robokop.renci.org/api/simple/expand/gene/HGNC:9353/chemical_substance/
API 4.70: https://robokop.renci.org/api/simple/expand/gene/HGNC:21218/chemical_substance/
API 4.77: https://robokop.renci.org/api/simple/expand/gene/HGNC:21595/chemical_substance/
API 4.71: https://robokop.renci.org/api/simple/expand/gene/HGNC:9949/chemical_substance/
API 4.72: https://robokop.renci.org/api/simple/expand/gene/HGNC:1108/chemical_substance/
API 4.67: https://robokop.renci.org/api/simple/expand/gene/HGNC:8607/chemical_substance/
API 4.76: https://robokop.renci.org/api/simple/expand/gene/HGNC:29812/chemical_substance/
API 4.73: https://robokop.renci.org/api/simple/expand/gene/HGNC:391/chemical_substance/
API 4.69: https://robokop.renci.org/api/simple/expand/gene/HGNC:9412/chemical_substance/


==== Step #3: Output normalization ====

API 3.1 dgidb_gene2chemical: 2 hits
API 3.2 dgidb_gene2chemical: 3 hits
API 3.3 dgidb_gene2chemical: 149 hits
API 3.4 dgidb_gene2chemical: 2 hits
API 3.5 dgidb_gene2chemical: No hits
API 3.6 dgidb_gene2chemical: No hits
API 3.7 dgidb_gene2chemical: 15 hits
API 3.8 dgidb_gene2chemical: 35 hits
API 3.9 dgidb_gene2chemical: No hits
API 3.10 dgidb_gene2chemical: No hits
API 3.11 dgidb_gene2chemical: 1 hits
API 3.12 dgidb_gene2chemical: No hits
API 3.13 dgidb_gene2chemical: 1 hits
API 3.14 dgidb_gene2chemical: 20 hits
API 3.15 dgidb_gene2chemical: 2 hits
API 3.16 dgidb_gene2chemical: 2 hits
API 3.17 dgidb_gene2chemical: No hits
API 3.18 dgidb_gene2chemical: No hits
API 3.19 dgidb_gene2chemical: No hits
API 3.20 dgidb_gene2chemical: 1 hits
API 3.21 dgidb_gene2chemical: No hits
API 3.22 dgidb_gene2chemical: No hits
API 3.23 dgidb_gene2chemical: 1 hits
API 3.24 dgidb_gene2chemical: 1 hits
API 3.25 dgidb_gene2chemical: No hits
API 3.26 dgidb_gene2chemical: No hits
API 3.27 dgidb_gene2chemical: No hits
API 3.28 dgidb_gene2chemical: No hits
API 3.29 dgidb_gene2chemical: No hits
API 3.30 dgidb_gene2chemical: 29 hits
API 3.31 dgidb_gene2chemical: No hits
API 3.32 dgidb_gene2chemical: 104 hits
API 3.33 dgidb_gene2chemical: 1 hits
API 3.34 dgidb_gene2chemical: No hits
API 3.35 dgidb_gene2chemical: 13 hits
API 3.36 dgidb_gene2chemical: No hits
API 3.37 dgidb_gene2chemical: 1 hits
API 3.38 dgidb_gene2chemical: 3 hits
API 3.39 dgidb_gene2chemical: No hits
API 3.40 dgidb_gene2chemical: 2 hits
API 3.41 dgidb_gene2chemical: No hits
API 3.42 dgidb_gene2chemical: 8 hits
API 3.43 dgidb_gene2chemical: 20 hits
API 3.44 dgidb_gene2chemical: 3 hits
API 3.45 dgidb_gene2chemical: 2 hits
API 3.46 dgidb_gene2chemical: No hits
API 3.47 dgidb_gene2chemical: No hits
API 3.48 dgidb_gene2chemical: 37 hits
API 3.49 dgidb_gene2chemical: No hits
API 3.50 dgidb_gene2chemical: 3 hits
API 3.51 dgidb_gene2chemical: 1 hits
API 3.52 dgidb_gene2chemical: No hits
API 3.53 dgidb_gene2chemical: 14 hits
API 3.54 dgidb_gene2chemical: No hits
API 3.55 dgidb_gene2chemical: 1 hits
API 3.56 dgidb_gene2chemical: No hits
API 3.57 dgidb_gene2chemical: 15 hits
API 3.58 dgidb_gene2chemical: No hits
API 3.59 dgidb_gene2chemical: No hits
API 3.60 dgidb_gene2chemical: 1 hits
API 3.61 dgidb_gene2chemical: No hits
API 3.62 dgidb_gene2chemical: No hits
API 3.63 dgidb_gene2chemical: 1 hits
API 3.64 dgidb_gene2chemical: No hits
API 3.65 dgidb_gene2chemical: 3 hits
API 3.66 dgidb_gene2chemical: No hits
API 3.67 dgidb_gene2chemical: No hits
API 3.68 dgidb_gene2chemical: No hits
API 3.69 dgidb_gene2chemical: 80 hits
API 3.70 dgidb_gene2chemical: 9 hits
API 3.71 dgidb_gene2chemical: 1 hits
API 3.72 dgidb_gene2chemical: No hits
API 3.73 dgidb_gene2chemical: 2 hits
API 3.74 dgidb_gene2chemical: No hits
API 3.75 dgidb_gene2chemical: No hits
API 3.76 dgidb_gene2chemical: No hits
API 3.77 dgidb_gene2chemical: No hits
API 3.78 dgidb_gene2chemical: 10 hits
API 3.79 dgidb_gene2chemical: No hits
API 3.80 dgidb_gene2chemical: No hits
API 3.81 dgidb_gene2chemical: 2 hits
API 3.82 dgidb_gene2chemical: 7 hits
API 3.83 dgidb_gene2chemical: No hits
API 3.84 dgidb_gene2chemical: No hits
API 3.85 dgidb_gene2chemical: No hits
API 3.86 dgidb_gene2chemical: 8 hits
API 3.87 dgidb_gene2chemical: No hits
API 3.88 dgidb_gene2chemical: No hits
API 3.89 dgidb_gene2chemical: No hits
API 3.90 dgidb_gene2chemical: No hits
API 3.91 dgidb_gene2chemical: No hits
API 3.92 dgidb_gene2chemical: No hits
API 3.93 dgidb_gene2chemical: 7 hits
API 3.94 dgidb_gene2chemical: No hits
API 3.95 dgidb_gene2chemical: No hits
API 3.96 dgidb_gene2chemical: No hits
API 3.97 dgidb_gene2chemical: No hits
API 3.98 dgidb_gene2chemical: No hits
API 3.99 dgidb_gene2chemical: No hits
API 3.100 dgidb_gene2chemical: No hits
API 3.101 dgidb_gene2chemical: No hits
API 3.102 dgidb_gene2chemical: No hits
API 3.103 dgidb_gene2chemical: No hits
API 3.104 dgidb_gene2chemical: 4 hits
API 3.105 dgidb_gene2chemical: No hits
API 3.106 dgidb_gene2chemical: No hits
API 3.107 dgidb_gene2chemical: No hits
API 3.108 dgidb_gene2chemical: No hits
API 3.109 dgidb_gene2chemical: 13 hits
API 3.110 dgidb_gene2chemical: 33 hits
API 3.111 dgidb_gene2chemical: No hits
API 3.112 dgidb_gene2chemical: No hits
API 3.113 dgidb_gene2chemical: No hits
API 3.114 dgidb_gene2chemical: No hits
API 3.115 dgidb_gene2chemical: No hits
API 3.116 dgidb_gene2chemical: No hits
API 3.117 dgidb_gene2chemical: No hits
API 3.118 dgidb_gene2chemical: No hits
API 3.119 dgidb_gene2chemical: No hits
API 3.120 dgidb_gene2chemical: No hits
API 3.121 dgidb_gene2chemical: No hits
API 3.122 dgidb_gene2chemical: No hits
API 3.123 dgidb_gene2chemical: No hits
API 3.124 dgidb_gene2chemical: 142 hits
API 3.125 dgidb_gene2chemical: 1 hits
API 3.126 dgidb_gene2chemical: No hits
API 3.127 dgidb_gene2chemical: 146 hits
API 3.128 dgidb_gene2chemical: No hits
API 3.129 dgidb_gene2chemical: No hits
API 3.130 dgidb_gene2chemical: 2 hits
API 3.131 dgidb_gene2chemical: No hits
API 3.132 dgidb_gene2chemical: 3 hits
API 3.133 dgidb_gene2chemical: No hits
API 3.134 dgidb_gene2chemical: No hits
API 3.135 dgidb_gene2chemical: No hits
API 3.136 dgidb_gene2chemical: 11 hits
API 3.137 dgidb_gene2chemical: No hits
API 3.138 dgidb_gene2chemical: 48 hits
API 3.139 dgidb_gene2chemical: 67 hits
API 3.140 dgidb_gene2chemical: No hits
API 3.141 dgidb_gene2chemical: No hits
API 3.142 dgidb_gene2chemical: 3 hits
API 3.143 dgidb_gene2chemical: No hits
API 3.144 dgidb_gene2chemical: 1 hits
API 3.145 dgidb_gene2chemical: No hits
API 3.146 dgidb_gene2chemical: No hits
API 1.1 mychem.info: 19 hits
API 1.2 mychem.info: 518 hits
API 1.3 mychem.info: 301 hits
API 2.1 opentarget: No hits
API 2.2 opentarget: 15 hits
API 2.3 opentarget: No hits
API 2.4 opentarget: No hits
API 2.5 opentarget: No hits
API 2.6 opentarget: No hits
API 2.7 opentarget: No hits
API 2.8 opentarget: No hits
API 2.9 opentarget: No hits
API 2.10 opentarget: No hits
API 2.11 opentarget: No hits
API 2.12 opentarget: No hits
API 2.13 opentarget: 15 hits
API 2.14 opentarget: No hits
API 2.15 opentarget: No hits
API 2.16 opentarget: No hits
API 2.17 opentarget: No hits
API 2.18 opentarget: No hits
API 2.19 opentarget: No hits
API 2.20 opentarget: No hits
API 2.21 opentarget: No hits
API 2.22 opentarget: 2 hits
API 2.23 opentarget: No hits
API 2.24 opentarget: No hits
API 2.25 opentarget: No hits
API 2.26 opentarget: No hits
API 2.27 opentarget: No hits
API 2.28 opentarget: 15 hits
API 2.29 opentarget: No hits
API 2.30 opentarget: No hits
API 2.31 opentarget: No hits
API 2.32 opentarget: 15 hits
API 2.33 opentarget: No hits
API 2.34 opentarget: No hits
API 2.35 opentarget: No hits
API 2.36 opentarget: No hits
API 2.37 opentarget: 10 hits
API 2.38 opentarget: 15 hits
API 2.39 opentarget: 15 hits
API 2.40 opentarget: No hits
API 2.41 opentarget: No hits
API 2.42 opentarget: No hits
API 2.43 opentarget: No hits
API 2.44 opentarget: 15 hits
API 2.45 opentarget: No hits
API 2.46 opentarget: No hits
API 2.47 opentarget: No hits
API 2.48 opentarget: No hits
API 2.49 opentarget: No hits
API 2.50 opentarget: No hits
API 2.51 opentarget: No hits
API 2.52 opentarget: No hits
API 2.53 opentarget: No hits
API 2.54 opentarget: No hits
API 2.55 opentarget: No hits
API 2.56 opentarget: No hits
API 2.57 opentarget: No hits
API 2.58 opentarget: No hits
API 2.59 opentarget: No hits
API 2.60 opentarget: No hits
API 2.61 opentarget: No hits
API 2.62 opentarget: No hits
API 2.63 opentarget: No hits
API 2.64 opentarget: No hits
API 2.65 opentarget: No hits
API 2.66 opentarget: 15 hits
API 2.67 opentarget: 1 hits
API 2.68 opentarget: No hits
API 2.69 opentarget: No hits
API 2.70 opentarget: No hits
API 2.71 opentarget: No hits
API 2.72 opentarget: No hits
API 2.73 opentarget: No hits
API 2.74 opentarget: 15 hits
API 2.75 opentarget: No hits
API 2.76 opentarget: No hits
API 2.77 opentarget: No hits
API 2.78 opentarget: No hits
API 2.79 opentarget: 15 hits
API 2.80 opentarget: No hits
API 2.81 opentarget: No hits
API 2.82 opentarget: No hits
API 2.83 opentarget: No hits
API 2.84 opentarget: No hits
API 2.85 opentarget: 15 hits
API 2.86 opentarget: No hits
API 2.87 opentarget: No hits
API 2.88 opentarget: No hits
API 2.89 opentarget: No hits
API 2.90 opentarget: No hits
API 2.91 opentarget: No hits
API 2.92 opentarget: No hits
API 2.93 opentarget: No hits
API 2.94 opentarget: No hits
API 2.95 opentarget: No hits
API 2.96 opentarget: No hits
API 2.97 opentarget: No hits
API 2.98 opentarget: No hits
API 2.99 opentarget: 10 hits
API 2.100 opentarget: No hits
API 2.101 opentarget: No hits
API 2.102 opentarget: No hits
API 2.103 opentarget: No hits
API 2.104 opentarget: No hits
API 2.105 opentarget: No hits
API 2.106 opentarget: No hits
API 2.107 opentarget: No hits
API 2.108 opentarget: No hits
API 2.109 opentarget: No hits
API 2.110 opentarget: No hits
API 2.111 opentarget: No hits
API 2.112 opentarget: No hits
API 2.113 opentarget: No hits
API 2.114 opentarget: No hits
API 2.115 opentarget: No hits
API 2.116 opentarget: No hits
API 2.117 opentarget: No hits
API 2.118 opentarget: No hits
API 2.119 opentarget: No hits
API 2.120 opentarget: No hits
API 2.121 opentarget: No hits
API 2.122 opentarget: No hits
API 2.123 opentarget: No hits
API 2.124 opentarget: No hits
API 2.125 opentarget: No hits
API 2.126 opentarget: No hits
API 2.127 opentarget: 15 hits
API 2.128 opentarget: No hits
API 2.129 opentarget: No hits
API 2.130 opentarget: No hits
API 2.131 opentarget: 15 hits
API 2.132 opentarget: No hits
API 2.133 opentarget: No hits
API 2.134 opentarget: No hits
API 2.135 opentarget: No hits
API 2.136 opentarget: No hits
API 2.137 opentarget: No hits
API 2.138 opentarget: No hits
API 2.139 opentarget: No hits
API 2.140 opentarget: No hits
API 2.141 opentarget: No hits
API 2.142 opentarget: No hits
API 2.143 opentarget: No hits
API 2.144 opentarget: No hits
API 2.145 opentarget: No hits
API 2.146 opentarget: No hits
API 2.147 opentarget: No hits
API 2.148 opentarget: 3 hits
API 2.149 opentarget: No hits
API 2.150 opentarget: No hits
API 2.151 opentarget: No hits
API 2.152 opentarget: No hits
API 2.153 opentarget: No hits
API 2.154 opentarget: No hits
API 2.155 opentarget: No hits
API 2.156 opentarget: No hits
API 2.157 opentarget: No hits
API 2.158 opentarget: No hits
API 2.159 opentarget: No hits
API 2.160 opentarget: No hits
API 2.161 opentarget: No hits
API 2.162 opentarget: No hits
API 4.1 robokop_gene2chemical: No hits
API 4.2 robokop_gene2chemical: 7 hits
API 4.3 robokop_gene2chemical: No hits
API 4.4 robokop_gene2chemical: 19 hits
API 4.5 robokop_gene2chemical: 2 hits
API 4.6 robokop_gene2chemical: 9 hits
API 4.7 robokop_gene2chemical: No hits
API 4.8 robokop_gene2chemical: 4 hits
API 4.9 robokop_gene2chemical: 12 hits
API 4.10 robokop_gene2chemical: No hits
API 4.11 robokop_gene2chemical: 7 hits
API 4.12 robokop_gene2chemical: 1 hits
API 4.13 robokop_gene2chemical: No hits
API 4.14 robokop_gene2chemical: No hits
API 4.15 robokop_gene2chemical: 1 hits
API 4.16 robokop_gene2chemical: 2 hits
API 4.17 robokop_gene2chemical: No hits
API 4.18 robokop_gene2chemical: No hits
API 4.19 robokop_gene2chemical: 18 hits
API 4.20 robokop_gene2chemical: 66 hits
API 4.21 robokop_gene2chemical: No hits
API 4.22 robokop_gene2chemical: No hits
API 4.23 robokop_gene2chemical: No hits
API 4.24 robokop_gene2chemical: No hits
API 4.25 robokop_gene2chemical: No hits
API 4.26 robokop_gene2chemical: 2 hits
API 4.27 robokop_gene2chemical: No hits
API 4.28 robokop_gene2chemical: 39 hits
API 4.29 robokop_gene2chemical: No hits
API 4.30 robokop_gene2chemical: No hits
API 4.31 robokop_gene2chemical: No hits
API 4.32 robokop_gene2chemical: No hits
API 4.33 robokop_gene2chemical: 2 hits
API 4.34 robokop_gene2chemical: 2 hits
API 4.35 robokop_gene2chemical: No hits
API 4.36 robokop_gene2chemical: No hits
API 4.37 robokop_gene2chemical: 1 hits
API 4.38 robokop_gene2chemical: No hits
API 4.39 robokop_gene2chemical: No hits
API 4.40 robokop_gene2chemical: 2 hits
API 4.41 robokop_gene2chemical: No hits
API 4.42 robokop_gene2chemical: No hits
API 4.43 robokop_gene2chemical: No hits
API 4.44 robokop_gene2chemical: No hits
API 4.45 robokop_gene2chemical: No hits
API 4.46 robokop_gene2chemical: No hits
API 4.47 robokop_gene2chemical: No hits
API 4.48 robokop_gene2chemical: 6 hits
API 4.49 robokop_gene2chemical: 3 hits
API 4.50 robokop_gene2chemical: No hits
API 4.51 robokop_gene2chemical: No hits
API 4.52 robokop_gene2chemical: No hits
API 4.53 robokop_gene2chemical: No hits
API 4.54 robokop_gene2chemical: No hits
API 4.55 robokop_gene2chemical: No hits
API 4.56 robokop_gene2chemical: 2 hits
API 4.57 robokop_gene2chemical: No hits
API 4.58 robokop_gene2chemical: 26 hits
API 4.59 robokop_gene2chemical: No hits
API 4.60 robokop_gene2chemical: No hits
API 4.61 robokop_gene2chemical: No hits
API 4.62 robokop_gene2chemical: 1 hits
API 4.63 robokop_gene2chemical: No hits
API 4.64 robokop_gene2chemical: No hits
API 4.65 robokop_gene2chemical: 3 hits
API 4.66 robokop_gene2chemical: No hits
API 4.67 robokop_gene2chemical: 1 hits
API 4.68 robokop_gene2chemical: No hits
API 4.69 robokop_gene2chemical: 1 hits
API 4.70 robokop_gene2chemical: No hits
API 4.71 robokop_gene2chemical: No hits
API 4.72 robokop_gene2chemical: No hits
API 4.73 robokop_gene2chemical: 23 hits
API 4.74 robokop_gene2chemical: 1 hits
API 4.75 robokop_gene2chemical: 7 hits
API 4.76 robokop_gene2chemical: 1 hits
API 4.77 robokop_gene2chemical: No hits
API 4.78 robokop_gene2chemical: No hits
API 4.79 robokop_gene2chemical: No hits
API 4.80 robokop_gene2chemical: No hits
API 4.81 robokop_gene2chemical: No hits
API 4.82 robokop_gene2chemical: No hits
API 4.83 robokop_gene2chemical: No hits
API 4.84 robokop_gene2chemical: No hits
API 4.85 robokop_gene2chemical: No hits
API 4.86 robokop_gene2chemical: No hits
API 4.87 robokop_gene2chemical: No hits
API 4.88 robokop_gene2chemical: No hits
API 4.89 robokop_gene2chemical: No hits
API 4.90 robokop_gene2chemical: No hits
API 4.91 robokop_gene2chemical: No hits
API 4.92 robokop_gene2chemical: No hits
API 4.93 robokop_gene2chemical: No hits
API 4.94 robokop_gene2chemical: No hits
API 4.95 robokop_gene2chemical: No hits
API 4.96 robokop_gene2chemical: No hits
API 4.97 robokop_gene2chemical: No hits
API 4.98 robokop_gene2chemical: No hits
API 4.99 robokop_gene2chemical: No hits
API 4.100 robokop_gene2chemical: No hits
API 4.101 robokop_gene2chemical: No hits
API 4.102 robokop_gene2chemical: No hits
API 4.103 robokop_gene2chemical: No hits
API 4.104 robokop_gene2chemical: No hits
API 4.105 robokop_gene2chemical: No hits
API 4.106 robokop_gene2chemical: No hits
API 4.107 robokop_gene2chemical: No hits
API 4.108 robokop_gene2chemical: No hits
API 4.109 robokop_gene2chemical: No hits
API 4.110 robokop_gene2chemical: No hits
API 4.111 robokop_gene2chemical: No hits
API 4.112 robokop_gene2chemical: No hits
API 4.113 robokop_gene2chemical: No hits
API 4.114 robokop_gene2chemical: No hits
API 4.115 robokop_gene2chemical: No hits
API 4.116 robokop_gene2chemical: No hits
API 4.117 robokop_gene2chemical: No hits
API 4.118 robokop_gene2chemical: No hits
API 4.119 robokop_gene2chemical: No hits
API 4.120 robokop_gene2chemical: No hits
API 4.121 robokop_gene2chemical: No hits
API 4.122 robokop_gene2chemical: No hits
API 4.123 robokop_gene2chemical: No hits
API 4.124 robokop_gene2chemical: No hits
API 4.125 robokop_gene2chemical: No hits
API 4.126 robokop_gene2chemical: No hits
API 4.127 robokop_gene2chemical: No hits
API 4.128 robokop_gene2chemical: No hits
API 4.129 robokop_gene2chemical: No hits
API 4.130 robokop_gene2chemical: No hits
API 4.131 robokop_gene2chemical: No hits
API 4.132 robokop_gene2chemical: No hits
API 4.133 robokop_gene2chemical: No hits
API 4.134 robokop_gene2chemical: No hits
API 4.135 robokop_gene2chemical: No hits
API 4.136 robokop_gene2chemical: No hits
API 4.137 robokop_gene2chemical: No hits
API 4.138 robokop_gene2chemical: No hits
API 4.139 robokop_gene2chemical: No hits
API 4.140 robokop_gene2chemical: No hits
API 4.141 robokop_gene2chemical: No hits
API 4.142 robokop_gene2chemical: No hits
API 4.143 robokop_gene2chemical: No hits
API 4.144 robokop_gene2chemical: No hits
API 4.145 robokop_gene2chemical: No hits
API 4.146 robokop_gene2chemical: No hits
API 5.1 semmedgene: 25595 hits

After id-to-object translation, BTE retrieved 6103 unique objects.

==========
========== Final assembly of results ==========
==========


In the #1 query, BTE found 218 unique Gene nodes
In the #2 query, BTE found 6103 unique ChemicalSubstance nodes

















In [3]:



    


df = fc.display_table_view()

The df object contains the full output from BioThings Explorer. Each row shows one path that joins the input node (PRDX1) to an intermediate node (a gene or protein) to an ending node (a chemical compound). The data frame includes a set of columns with additional details on each node and edge (including human-readable labels, identifiers, and sources). Let's remove all examples where the output_name (the compound label) is None, and specifically focus on paths with specific mechanistic predicates decreasesActivityOf and targetedBy.

Filter for drugs that targets genes which decrease the activity of PRDX1





In [15]:



    


dfFilt = df.loc[df['output_name'].notnull()].query('pred1 == "decreasesActivityOf" and pred2 == "targetedBy"')
dfFilt



    


















    
Out[15]:











  
    

      
      input
      input_type
      pred1
      pred1_source
      pred1_api
      pred1_pubmed
      node1_id
      node1_name
      node1_type
      pred2
      pred2_source
      pred2_api
      pred2_pubmed
      output_id
      output_name
      output_type
    

  
  
    

      215
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7422
      VEGFA
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      drugbank:DB14864
      DB14864
      ChemicalSubstance
    

    

      346
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7422
      VEGFA
      Gene
      targetedBy
      dgidb
      dgidb_gene2chemical
      None
      chembl:CHEMBL799
      CILOSTAZOL
      ChemicalSubstance
    

    

      512
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:1385
      CREB1
      Gene
      targetedBy
      dgidb
      dgidb_gene2chemical
      None
      chembl:CHEMBL3
      NICOTINE
      ChemicalSubstance
    

    

      793
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7124
      TNF
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      chembl:CHEMBL1201831
      CERTOLIZUMAB PEGOL
      ChemicalSubstance
    

    

      899
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7124
      TNF
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      chembl:CHEMBL173373
      ethyl pyruvate
      ChemicalSubstance
    

    

      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
      ...
    

    

      32292
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7124
      TNF
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      chembl:CHEMBL2103838
      DILMAPIMOD
      ChemicalSubstance
    

    

      32321
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:10013
      HDAC6
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      chembl:CHEMBL98
      VORINOSTAT
      ChemicalSubstance
    

    

      32322
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:10013
      HDAC6
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      chembl:CHEMBL98
      VORINOSTAT
      ChemicalSubstance
    

    

      32652
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7422
      VEGFA
      Gene
      targetedBy
      dgidb
      dgidb_gene2chemical
      None
      chembl:CHEMBL16
      PHENYTOIN
      ChemicalSubstance
    

    

      33232
      PRDX1
      Gene
      decreasesActivityOf
      semmed
      semmedgene
      
      entrez:7124
      TNF
      Gene
      targetedBy
      mychem.info
      mychem.info
      None
      drugbank:DB10770
      DB10770
      ChemicalSubstance
    

  



132 rows × 16 columns



















In [22]:



    


dfFilt.node1_id.unique()



    


















    
Out[22]:








array(['entrez:7422', 'entrez:1385', 'entrez:7124', 'entrez:10013',
       'entrez:5657', 'entrez:4547'], dtype=object)

















In [25]:



    


dfFilt.node1_name.unique()



    


















    
Out[25]:








array(['VEGFA', 'CREB1', 'TNF', 'HDAC6', 'PRTN3', 'MTTP'], dtype=object)

Step 3: Evaluating Paths based on published pathway figures

Let's see if PRDX1 (entrez:5052) is in the same pathway as TNF (entrez:7124) using our newly created API PFOCR





In [27]:



    


import requests

# query pfocr to see if PRDX1 and VEGFA is in the same pathway figure
doc = requests.get('https://pending.biothings.io/pfocr/query?q=associatedWith.genes:5052 AND associatedWith.genes:7124').json()
doc



    


















    
Out[27]:








{'max_score': 9.817886,
 'took': 2,
 'total': 1,
 'hits': [{'_id': 'PMC4749872__molce-39-1-40f1.jpg',
   '_score': 9.817886,
   'associatedWith': {'figureUrl': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749872/bin/molce-39-1-40f1.jpg',
    'genes': ['11221',
     '1432',
     '1843',
     '3163',
     '369',
     '4217',
     '4297',
     '5052',
     '5594',
     '5595',
     '5599',
     '5600',
     '5601',
     '5602',
     '5603',
     '5604',
     '5605',
     '5606',
     '5607',
     '5608',
     '5609',
     '5894',
     '6300',
     '6416',
     '673',
     '7124',
     '7180'],
    'pmc': 'PMC4749872'}}]}

image of PMC4749872__molce-39-1-40f1.jpg

Content source: biothings/biothings_explorer

Similar notebooks:

notebook.community | gallery | about